Jonathan C Cohen Selected Research

Sitosterolemia

2/2015	Relative roles of ABCG5/ABCG8 in liver and intestine.
11/2010	Identification by whole-genome resequencing of gene defect responsible for severe hypercholesterolemia.
2/2006	Functional asymmetry of nucleotide-binding domains in ABCG5 and ABCG8.
12/2004	No association between plasma levels of plant sterols and atherosclerosis in mice and men.
6/2004	Missense mutations in ABCG5 and ABCG8 disrupt heterodimerization and trafficking.
2/2004	Selective sterol accumulation in ABCG5/ABCG8-deficient mice.
12/2002	Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion.
9/2002	Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface.
3/2002	Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8.

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Jonathan C Cohen Research Topics

Disease

11	Atherosclerosis 01/2016 - 06/2004
9	Sitosterolemia 02/2015 - 03/2002
8	Coronary Disease (Coronary Heart Disease) 09/2014 - 12/2004
7	Hypercholesterolemia 11/2010 - 11/2002
6	Fatty Liver 01/2022 - 05/2016
6	Insulin Resistance 09/2015 - 12/2004
6	Hyperlipoproteinemia Type III (Broad Beta Disease) 01/2007 - 11/2002
5	Coronary Artery Disease (Coronary Atherosclerosis) 02/2015 - 04/2003
5	Non-alcoholic Fatty Liver Disease 01/2015 - 02/2010
4	Liver Diseases (Liver Disease) 01/2018 - 04/2012
3	Fibrosis (Cirrhosis) 01/2019 - 06/2011
3	Hypertriglyceridemia 10/2014 - 02/2011
3	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 05/2013 - 03/2006
2	Homozygous Familial Hypercholesterolemia 01/2020 - 11/2002
2	Xanthomatosis (Xanthoma) 11/2010 - 04/2003
2	Obesity 02/2010 - 04/2009
2	Dyslipidemias (Dyslipidemia) 04/2009 - 04/2003
1	Inflammation (Inflammations) 01/2019
1	Weight Loss (Weight Reduction) 01/2017
1	Hepatocellular Carcinoma (Hepatoma) 12/2015
1	Hyperlipidemias (Hyperlipidemia) 07/2015
1	Liver Neoplasms (Liver Cancer) 06/2011
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/2009
1	Overweight 04/2009
1	Hypertension (High Blood Pressure) 06/2007
1	Myocardial Infarction 03/2006
1	Cardiovascular Diseases (Cardiovascular Disease) 03/2005
1	Heart Septal Defects 07/2003

Drug/Important Bio-Agent (IBA)

12	oxidized low density lipoproteinIBA 01/2020 - 11/2002
9	Triglycerides (Triacylglycerol)IBA 01/2019 - 04/2007
9	Proteins (Proteins, Gene)FDA Link 01/2019 - 07/2003
7	SterolsIBA 01/2016 - 09/2002
6	LDL Receptors (LDL Receptor)IBA 05/2013 - 11/2002
6	LDL CholesterolIBA 05/2013 - 03/2006
5	CholesterolIBA 11/2010 - 02/2004
4	Phospholipases (Phospholipase)IBA 01/2019 - 10/2010
4	Phytosterols (Plant Sterols)IBA 09/2006 - 03/2002
3	ApolipoproteinsIBA 01/2022 - 02/2011
3	LipidsIBA 01/2022 - 04/2009
3	LDL Lipoproteins (beta Lipoproteins)IBA 05/2013 - 11/2002
3	Proprotein Convertase 9IBA 09/2006 - 03/2006
2	Lipoproteins (Lipoprotein)IBA 01/2022 - 06/2007
2	Insulin ReceptorIBA 11/2021 - 10/2014
2	Glucose (Dextrose)FDA LinkGeneric 09/2015 - 03/2010
2	gamma-sitosterol (beta-sitosterol)IBA 11/2010 - 12/2004
2	Serine Proteases (Serine Protease)IBA 03/2006 - 03/2006
2	Adenosine Triphosphate (ATP)IBA 12/2002 - 09/2002
2	PhosphotyrosineIBA 11/2002 - 11/2002
1	Glutamic Acid (Glutamate)FDA Link 01/2022
1	Lysine (L-Lysine)FDA Link 01/2022
1	Alanine Transaminase (SGPT)IBA 01/2018
1	Sucrose (Saccharose)IBA 10/2017
1	Monoclonal AntibodiesIBA 01/2017
1	VLDL LipoproteinsIBA 05/2016
1	Amino Acids FDA Link 12/2015
1	AdenosylhomocysteinaseIBA 12/2015
1	evinacumabIBA 07/2015
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2015
1	HydrolasesIBA 11/2012
1	Heparin (Liquaemin)FDA LinkGeneric 05/2012
1	Bile Acids and Salts (Bile Acids)IBA 04/2012
1	Protein Isoforms (Isoforms)IBA 10/2011
1	Apolipoproteins E (ApoE)IBA 11/2010
1	Apolipoproteins B (ApoB)IBA 11/2010
1	low density lipoprotein inhibitorIBA 04/2009
1	SubtilisinIBA 04/2009
1	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA 04/2009
1	AdiponectinIBA 04/2009
1	HDL CholesterolIBA 04/2007
1	Nonsense Codon (Nonsense Mutation)IBA 03/2006
1	ClathrinIBA 12/2005
1	Lipoprotein(a)IBA 03/2005
1	Ethanol (Ethyl Alcohol)IBA 12/2004
1	campesterolIBA 12/2004
1	CalciumIBA 12/2004

Therapy/Procedure

1	Ligation 11/2010